When a young ski team training for the Olympics arrives at the remote and isolated Lost Mountain Ski Resort to focus on training, they’re thrilled to find “Dash” Dashiell, (Patrick Muldoon), a retired Olympic skier, is there to help them train. But their plans are halted when Dr. April Sommers (Vanessa Williams), a scientist working at a nearby government lab, arrives with an emergency: giant spiders bred at the lab have escaped, and they’re killing and eating everything in sight!

A DNA experiment on a rare breed of spider is taking place on a NASA space shuttle, when a freak meteor shower engulfs the shuttle, causing everything to go horribly wrong. One survivor is found on the ship and watched over in a secret location deep in the California desert. The problem continues, as the survivor isn t alone, as another deadly spiders climbs out of him and goes on a rampage around the ship. Curious reporter Marci Eyre must now survive, escape and warn everyone before the spider reaches outside the desert.